They are very similar concepts, but Guix is configured using Scheme (specifically GNU Guile), instead of the crazy nixos language.

Choose Nixos Guix and get both!

I’m not the op, but I’ve been using guix for several months on a new fairly top of the line desktop PC and it’s going great. I’ve been able to play steam games and set up my dev environment with basically no issues.

The catch is you need to use non-official repositories (i.e. https://github.com/nonguix/nonguix) to use the non-libre kernel and other software not on the official channel.

There’s also this nice little search engine - https://toys.whereis.みんな/ - where you can look for packages from other repos (or channels as they are called in guix).

I use Nix on my macos work laptop to set up my dev environment, but I definitely prefer guix so far, mostly due to the it being configured in guile over the weird nix language. The biggest advantage I see of Nix is that it has a bit more features and lots more packages.

I am a pretty hardcore emacs user and lisp lover though, so ymmv.

The real learning happens when you copy and paste something you shouldn’t and bork your system. That’s basically how I started.