Yep, there are ways to do a full installation onto a thumb drive.
While It’s not exactly complex. It does tend to require more understanding of how file system mounting works than the audience OP is indicating would have.
It is likely time to create a user/id10t friendly app designed to download and fully install any ISO as a live thumb drive.
That will still need some help for odd hardware. But for most it would be a fair option.
Not to mention the vibration of the head caused from a single mount point. The engineerinh to keep anything close to the 0.2mm resolution common on non mobile printers. Will be expensive.