I think the reason this chart doesn’t feel right is because for substances we regularly ingest, a more useful scale would be the ratio of the lethal dose to the effective dose, since we use a different mg amount to get high on THC than we use to lower pain on acetaminophen
This is why grapefruit is so dangerous for so many medicines. Those medicines take bioavailability into account and can be a massive dose in some cases. Grapefruit keeps the same mechanism that lowers effective dosage busy, substantially increasing the effective dose - straight into overdose territory in some cases.
I think the reason this chart doesn’t feel right is because for substances we regularly ingest, a more useful scale would be the ratio of the lethal dose to the effective dose, since we use a different mg amount to get high on THC than we use to lower pain on acetaminophen
This is why grapefruit is so dangerous for so many medicines. Those medicines take bioavailability into account and can be a massive dose in some cases. Grapefruit keeps the same mechanism that lowers effective dosage busy, substantially increasing the effective dose - straight into overdose territory in some cases.